Banana as a Natural Superdisintegrant

Banana as a Natural Superdisintegrant The objective of the study was to evaluate banana powder as a superdisintegrant for the formulation of oral disintegrating tablets and to compare the results with commonly used superdisintegrants like croscarmellose sodium, pre gelatinised starch and sodium starch glycolate. Oral disintegrating tablets containing Domperidone as the model drug were formulated using five different concentrations of each superdisintegrant (2%, 4%, 6%, 8% & 10%) and compressed by direct compression. The formulations were subjected to various evaluation studies such as wetting time, water absorption ratio, disintegration time and in-vitro dissolution. The results showed that the disintegration time and drug release of the formulation containing banana powder (6%) was comparable to other super disintegrants. The IR spectrum analysis demonstrated that banana powder was compatible with the drug. These results suggest that banana powder can be used effectively as a superdisintegrant in orally disintegrating tablet formulations. Banana, is a natural product which is available in plenty, economically affordable and has its own nutritional value. It can be used as a potential additive in the formulation of oro -dispersible tablets. Keyword: orodispersible tablets, superdisintegrants, disintegration time, natural excipients. INTRODUCTION The tablet is the widely used dosage form because of its convenience in terms of self-administration, compactness, and ease in manufacturing. For the past one decade, there has been a demand for more patient-friendly and compliant dosage forms. As a result, the development of new technologies has been increasing annually. Since the cost for development new drug molecule is very high, efforts are now being made by pharmaceutical companies to focus on the development of new drug dosage forms for existing drugs with more safety and efficacy together with reduced dosing frequency, and the production of more cost-effective dosage forms. However, geriatric and p ediatric patients were having difficulty in swallowing conventional tablets, which leads to poor patient compliance. To overcome this problem, scientists have developed innovative drug delivery systems known as â€Å"melt in mouth† or â€Å"mouth dissolve (MD)† or sometimes â€Å"dispersible† tablets. These are novel types of tablets that disintegrate /disperse in saliva. Their characteristic advantages such as administration without water, lead to suitability for the geriatric and pediatric patients. They are also suitable for the bedridden patients, and patients who do not have easy access to water. The advantages, in terms of patient compliance, rapid onset of action, increased bioavailability (in some instances) and comparable stability to conventional tablets make these tablets popular as a dosage form of choice particularly in these populations. Domperidone maleate is a widely used anti-emetic drug, acting by inhibition of the dopaminergic receptor. Domper idone maleate does not cross the blood brain barrier. Domperidone maleate is also effective in gastro paresis, pediatrics gastro esophageal reflux (infant vomiting). Domperidone maleate after oral dosing undergoes extensive gastric and hepatic first pass metabolism resulting in low bioavailability (15%) which therefore, may not minimize the rate of vomiting. In context of the above principles, a strong need was recognized for the development of mouth dissolving tablets of Domperidone maleate to improve its bioavailability for relief on nausea and vomiting. In mouth dissolving tablets, disintegrants plays a major role. A  disintegrant  is a substance in a tablet formulation that enables the tablet to break up into smaller fragments upon contact with gastrointestinal fluids. Such a rapid rupture of the tablet matrix increases the surface area of the tablet particles, thereby increasing the rate of absorption of the active ingredient and decreasing the onset of time to therapeutic effect. A new disintegrant class has emerged during the recent past known as the Superdisintegrant. Superdisintegrants improve disintegrant efficiency resulting in decreased use levels, typically 1-10% by weight relative to total weight of tablet when compared to traditional disintegrants.

An Empirical study of determinants of capital structure of Essay - 1

An Empirical study of determinants of capital structure of non-financial companies in Egypt before and after the financial crisis - Essay Example The current financial crisis therefore has significantly affected the financial institutions of the world along with other non-financial institutions also. Due to this reason, the overall extension of credit to the non-financial institutions has been affected over the period of time. It is however, important to note that international banks specially working in developing countries have relatively limited contacts or business relationships with the international banks therefore they have not been affected the way international banks have been. In countries like China where the financial sector is mostly under the control of government, banks exposure towards toxic debt is limited therefore despite having the international presence, these banks are not fully affected by these changes. It is also however, critical to understand that there is an indirect threat faced by the international banks due to general decline in the stock prices as well as the falling housing market. Since most of the banks do not keep most of their capital in the form of cash therefore declining asset values will force them to allocate more capital to cover the potential risks. In such an environment there are chances that the overall credit extension to private sector may decline and financial institutions may require the support of their governments to keep them solvent. Theory also suggests that a reduction in the bank credit may result into a decline in the investment activity in the country and this will invariably affect the growth and may result into the creation of unemployment within a country. Since most of the emerging countries such as China, India, Korea and Japan are depending on exports as their major economic variable for growth therefore the current financial crisis may result into the substantial decline in the export business and thus may

Investigation into Virtual Organisation facilities Coursework

Investigation into Virtual Organisation facilities - Coursework Example Growing complexity in the business environment makes "business as usual" ineffective. (Keen, 1991) Globalization calls for communication and synchronization across diverse time zones and locations. Time constraints require reduction in reaction time, driving businesses to just-in-time inventory, orders, scheduling, payments, manufacturing, distribution, etc. Change has become the norm, an unpredictable basic reality. The fresh economic cutting edge is the knowledge economy, and right now about 97% of all employment expansion is coming from knowledge work. Wealth today is generated principally by the value people add through new ideas. (Moyer, 1994) What members of these workgroups do is called collaborative work and they must often overcome barriers of time zones and geography to document what has been accomplished. (Stuck, 1995) To stay aggressive in today's business atmosphere requires new levels of collaboration and dexterity, both within and between organizations. Communications networks and IT are the tools that make possible this "working together apart," and telecommuting (or home working) is making workgroups more productive. (Stuck, 1995) IT plays a fundamental role in supporting critical activities, enabling organizations to make efficient and effective changes in the manner in which work is performed (Turban, 1996) and offering real potential for changing the way in which people work (Daniels, 1995). For example, the Internet provides a way for small businesses to create a virtual organization to complete projects (Blotzer, 1995). Companies are forming worldwide mutual provisions as the basis for developing a competitive advantage from technology (Bailetti, 1993). Coordination of IT management presents a real challenge to these firms which have to deal with detached, decentralized IT practices (DeSanctis, 1994). While decentralization may bring litheness and fast response to changing needs, it also makes systems integration difficult, presents' obstruction to standardization, and acts as a disincentive for achieving economies of scale (DeSanctis, 1994). In juxtaposition with rapid changes in the business environment, the way in which business is conducted is also changing at a rapid pace. Groups, not individuals, have become the fundamental unit of work in modern organizations, with non-routine and new work most often being accomplished through teams, committees, or ad hoc workgroups (Finholt, 1990). Groups and group behavior are momentous for both organizational performance and individual group members. Computer-based technology may affect these groups and their behavior. At least some electronic groups behave